[Apoproteins C and E from very low and high density lipoproteins in men with dysalphalipoproteinemia]

Abstract

Quantitative alterations were found in content and the ratio of apoproteins "C" and "E" from lipoproteins of very low density (LPVLD) and of high density (LPHD). In lipoproteinlipolysis of LPVLD the ratio of total apoprotein-inhibitors to protein-activators was increased in men with hyperalphalipoproteinemia; the lipoproteinlipolytic activity appears to depend on content and composition of specific LPVLD apoproteins. Dissimilar alterations in content of "C" and "E" apoproteins, studied in LPVLD and LPHD simultaneously, occurred when high and low concentrations of cholesterol-LPHD (CS-LPHD) were used. At the same time, content of apoE and cholesterol esters, occurring both in LPVLD and LPHD, was uniformly altered under conditions of CS-LPHD content variation. The data obtained suggest that content of blood plasma CS-LPHD is related to quantitative composition of apoproteins involved in regulation of lipoprotein metabolism in blood plasma.