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. 1982 Aug;14(2):247-56.
doi: 10.1111/j.1365-2125.1982.tb01969.x.

OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics

A W Kelman, B Whiting, S M Bryson

OPT: a package of computer programs for parameter optimisation in clinical pharmacokinetics

A W Kelman et al. Br J Clin Pharmacol. 1982 Aug.

Abstract

1 OPT is a series of computer programs designed to assist dose optimisation for individual patients. It is based on Bayesian Statistical Theory and Maximum Likelihood Estimation. 2 OPT uses prior information on the distribution of population pharmacokinetic parameters and plasma drug concentration measurements to obtain the "most likely' set of parameters for the individual. 3 Complex dosage regimes and non-steady state conditions can be handled. 4 OPT is designed for use in a Clinical Pharmacokinetics Laboratory where informed interpretation of results is essential. 5 The drugs for which the system is currently available include theophylline, digoxin, lignocaine, disopyramide, gentamicin and phenytoin (steady state data only).

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