[The utilization of parenterally administered amino acids in the postoperative phase. II. Calculation of an amino acid solution by pharmacokinetic criteria with 1st clinical trial]

Abstract

The composition of an amino acid (AA) solution suitable for the postoperative period was calculated on the basis of previously reported pharmacokinetic data, special attention being paid to the use of these data in pathological conditions. In preliminary clinical trials, 10 patients were infused with this solution during the first 3 postoperative days. AA blood levels were measured during continuous infusion of 1 g AA/kg body weight (BW)/day. Most AA blood levels normalized during infusion. 5 additional patients received increasing dosages (0.5, 1.0, 1.5, 2.0 and 5.0 g AA/kg BW/day) infused over 4 h. Nearly all blood levels lay within the normal range with dosages ranging from 0.75 to 1.5 g AA/kg BW/day.