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. 1978 Dec;75(6):1051-4.

Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome

I M Modlin, S R Bloom, S J Mitchell
  • PMID: 710857

Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome

I M Modlin et al. Gastroenterology. 1978 Dec.

Abstract

We have infused pure porcine vasoactive intestinal peptide (VIP) into 8 healthy ambulant unsedated pigs. At plasma VIP levels closely comparable to those found in the human Verner-Morrison syndrome, gross watery diarrhea and hypokalemia were produced. When the VIP infusion was discontinued the water diarrhea ceased abruptly. This study therefore provides some evidence to implicate VIP as a possible causal agent in the pathogenesis of the human watery diarrhea syndrome.

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