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. 1982 Sep 9;299(5879):126-31.
doi: 10.1038/299126a0.

Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin

V Bennett, J Davis, W E Fowler

Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin

V Bennett et al. Nature. .

Abstract

An immunoreactive analogue of erythrocyte spectrin has been purified from brain membranes. This protein co-sediments with and cross-links actin filaments, associates with spectrin-binding sites on erythrocyte membranes, and has been visualized by rotary shadowing as an extended, flexible rod. The brain spectrin comprises 3% of the total membrane protein, and may have a major role in mediating linkage of actin to membranes.

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