Renal calcifications: a complication of long-term furosemide therapy in preterm infants
- PMID: 7110808
Renal calcifications: a complication of long-term furosemide therapy in preterm infants
Abstract
During the last four years ten premature infants developed renal calcifications while receiving long-term furosemide therapy. The drug was used in infants with present ductus arteriosus and later in the same infants with chronic lung disease. They had received furosemide in a dose of at least 2 mg/kg/day for at least 12 days before calcifications were noted on abdominal roentgenograms. Calcifications included small flecks, isolated stones, staghorn calculi, and nephrocalcinosis. Analysis of stones received from our infants showed calcium oxalate and calcium phosphate. Infants who were not receiving furosemide had no calcifications. The infants with renal calcifications had rates of calcium excretion ten to 20 times that of normal, age-matched premature infants in our nursery. When chlorothiazide was given to the infants, in addition to furosemide, a four- to 15-fold decrease in calcium excretion and a radiologic dissolution of the renal calcifications were documented. It is concluded that furosemide, in doses of at least 2 mg/kg/day for at least 12 days can be associated with renal calcifications. The probable mechanism of the stone formation is hypercalciuria, primarily caused by furosemide.
Similar articles
-
Nephrolithiasis in premature infants.Radiology. 1985 Jan;154(1):107-10. doi: 10.1148/radiology.154.1.3964925. Radiology. 1985. PMID: 3964925
-
Furosemide promotes patent ductus arteriosus in premature infants with the respiratory-distress syndrome.N Engl J Med. 1983 Mar 31;308(13):743-8. doi: 10.1056/NEJM198303313081303. N Engl J Med. 1983. PMID: 6828120 Clinical Trial.
-
Secondary hyperparathyroidism and bone disease in infants receiving long-term furosemide therapy.Am J Dis Child. 1983 Dec;137(12):1157-61. doi: 10.1001/archpedi.1983.02140380017006. Am J Dis Child. 1983. PMID: 6637931
-
Furosemide and vitamin E. Two problem drugs in neonatology.Pediatr Clin North Am. 1986 Jun;33(3):583-602. Pediatr Clin North Am. 1986. PMID: 3520464 Review.
-
[Diuretics in the neonatal period].Rev Med Suisse Romande. 1995 Aug;115(8):583-90. Rev Med Suisse Romande. 1995. PMID: 7569538 Review. French.
Cited by
-
Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis.Pediatr Nephrol. 2019 Oct;34(10):1765-1776. doi: 10.1007/s00467-019-04293-9. Epub 2019 Jul 23. Pediatr Nephrol. 2019. PMID: 31338588 Free PMC article.
-
High incidence of nephrocalcinosis in extremely preterm infants treated with dexamethasone.Pediatr Radiol. 2004 Feb;34(2):138-42. doi: 10.1007/s00247-003-1090-7. Epub 2003 Nov 18. Pediatr Radiol. 2004. PMID: 14624322 Clinical Trial.
-
Urolithiasis in children: current medical management.Pediatr Nephrol. 1989 Jul;3(3):317-31. doi: 10.1007/BF00858542. Pediatr Nephrol. 1989. PMID: 2702115 Review.
-
Nephrocalcinosis in very low birth weight infants: incidence, associated factors, and natural course.Pediatr Nephrol. 2022 Dec;37(12):3093-3104. doi: 10.1007/s00467-021-05417-w. Epub 2022 Mar 28. Pediatr Nephrol. 2022. PMID: 35348900 Free PMC article.
-
Drug-induced urinary calculi.Rev Urol. 2003 Fall;5(4):227-31. Rev Urol. 2003. PMID: 16985842 Free PMC article.