Case Reports
doi: 10.1007/BF01962250.
Cyclosporin A: correlation between HPLC and RIA serum levels
- PMID: 7110912
- DOI: 10.1007/BF01962250
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Case Reports
Cyclosporin A: correlation between HPLC and RIA serum levels
Pharm Weekbl Sci.
.
Abstract
Serum levels of cyclosporin A were analysed in parallel with an HPLC and a RIA method for six patients who received repeated intramuscular and oral doses of this immunosuppressive drug after bone marrow transplantation. A good correlation was found between both methods with a similar time course of the serum curves. Due to cross-reacting metabolites, the values from the RIA assay were on average 30 to 100% higher than with the HPLC assay which is specific for the parent drug.
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