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Case Reports
. 1982 Jun 25;4(3):84-6.
doi: 10.1007/BF01962250.

Cyclosporin A: correlation between HPLC and RIA serum levels

E Abisch, T Beveridge, A Gratwohl, W Niederberger, K Nussbaumer, P Schaub, B Speck, M Trapp
Case Reports

Cyclosporin A: correlation between HPLC and RIA serum levels

E Abisch et al. Pharm Weekbl Sci. .

Abstract

Serum levels of cyclosporin A were analysed in parallel with an HPLC and a RIA method for six patients who received repeated intramuscular and oral doses of this immunosuppressive drug after bone marrow transplantation. A good correlation was found between both methods with a similar time course of the serum curves. Due to cross-reacting metabolites, the values from the RIA assay were on average 30 to 100% higher than with the HPLC assay which is specific for the parent drug.

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References

    1. Agents Actions. 1976 Jul;6(4):468-75 - PubMed
    1. Immunology. 1977 Jun;32(6):1017-25 - PubMed
    1. Br J Haematol. 1981 Jun;48(2):227-36 - PubMed
    1. J Immunoassay. 1981;2(1):19-32 - PubMed
    1. J Chromatogr. 1980 Jun 13;182(3-4):454-8 - PubMed

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