Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jun 15;26(6):401-9.
doi: 10.1016/0049-3848(82)90312-7.

Demonstration of a direct anti-factor Xa activity in certain heparin-related glycosaminoglycans

A Larsson, L A Fransson, W E Lewis

Demonstration of a direct anti-factor Xa activity in certain heparin-related glycosaminoglycans

A Larsson et al. Thromb Res. .

Abstract

Heparan sulphate/heparin subfractions with high plasma anti-Xa activity have an unusual uronate composition, i.e. high proportions of both glucuronate and sulphated iduronate. These preparations inhibit the amidase activity of factor Xa in an uncompetitive mode and the prothrombin-activation catalyzed by Xa, both in the absence of antithrombin III. Subfractions of low affinity for antithrombin III are equally potent against Xa. The anti-X activity is destroyed by a 3-h periodate oxidation.

PubMed Disclaimer

Publication types

LinkOut - more resources