[Effect of myocardial ischemia on the phospholipid composition of cardiac tissue and mitochondria]

Abstract

Concentration of lysophosphatidyl choline was slightly increased in heart tissue within 30 min after total rabbit myocardial ischemia and it was distinctly decreased within 1 hr as compared with control values. In the mitochondria within the initial periods (0.5 hr, 1 hr) of the ischemia concentration of lysophosphatidyl choline increased most markedly but the phospholipid content became similar to control level within 2 hrs. Alterations in the total phospholipid content whereas separate phospholipid fractions, lysophosphatidyl choline and cardiolipin, altered more distinctly in mitochondria. In ischemically impaired cell phospholipases appear to be initially involved in degradation of mitochondria phospholipids.