An etiological study on renal adenomas: with some references to dysplastic tubular lesions and adenocarcinomas in autopsy and surgery cases

Abstract

An etiological study on renal adenomas with specific references to dysplastic tubular lesions and adenocarcinomas was made, concentrating on histopathological and statistical surveys. Seventy-two unilateral kidneys obtained at random in autopsy cases were examined macro- amd microscopically on the consecutive sliced sections. Adenomas were found frequently in the cortex of 15 cases (20.8%), and particularly dysplastic tubular lesions were considerably associated with adenomas and detected even more frequently in 26 cases (36.2%), whereas fibromas in the medulla of 8 cases (11.1%). Most of the adenomas (86.7%) were found in nephrosclerotic kidneys; i.e., in vascular nephrosclerosis (53.4%), chronic pyelonephritis (13.3%), and in end-stage kidneys. The morphological feature of adenoma cells were also confirmed in the dysplastic tubular epithelial cells. These data imply that long-term renovascular and/or renostromal damages may induce dysplastic tubular lesions and further act as important enhancing or promoting factors on adult renal oncogenesis from the cortical tubular epithelium.