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. 1982 Aug;51(2):103-7.
doi: 10.1111/j.1600-0773.1982.tb00998.x.

Effects of penicillins in vitro on mucociliary activity of rabbit trachea

N G Toremalm, K Josefsson, K Klementsson, I Lagergren

Effects of penicillins in vitro on mucociliary activity of rabbit trachea

N G Toremalm et al. Acta Pharmacol Toxicol (Copenh). 1982 Aug.

Abstract

The effect of eight penicillins on the mucociliary activity of rabbit trachea was tested in vitro. Carbenicillin and ampicillin had a minor inhibitory effect. Penicillin G and V and pheneticillin were a little more ciliestatic. Propicillin, cloxacillin and dicloxacillin were most toxic. The mucociliary toxicity increased with increasing lipophilicity of the penicillins and correlated well with their known neurotoxic in vivo effects.

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