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. 1978 Oct;18(10):477-81.
doi: 10.1002/j.1552-4604.1978.tb01575.x.

Displacement of bilirubin from albumin by indomethacin

L F Rasmussen, C E Ahlfors, R P Wennberg

Displacement of bilirubin from albumin by indomethacin

L F Rasmussen et al. J Clin Pharmacol. 1978 Oct.

Abstract

The primary albumin binding site of indomethacin is remote from the bilirubin binding site. Indomethacin is, at most, a weak displacer of bilirubin at low serum drug concentrations. When administered at dosages less than 1 mg/kg, indomethacin would appear to be safe with respect to serum binding of bilirubin in premature infants.

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