Demonstration of cross-reacting tumor rejection antigens in chemically induced respiratory tract carcinomas in rats

Abstract

Experiments were performed to determine whether chemically induced rat respiratory tract carcinomas, which possess considerable immunogenicity, contain cross-reacting antigens. In vivo studies showed that effective cross-protection can be induced with four of the five respiratory tract cancers studied, suggesting that these tumors have common tumor rejection antigens. In vitro cytotoxicity studies with sera from tumor-immune hosts showed cross-reactivity among three of the carcinomas tested.