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Case Reports
. 1982 Aug;19(4):266-70.
doi: 10.1136/jmg.19.4.266.

Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa

L L Field, J R Heckenlively, R S Sparkes, C A Garcia, C Farson, D Zedalis, M C Sparkes, M Crist, S Tideman, M A Spence
Case Reports

Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa

L L Field et al. J Med Genet. 1982 Aug.

Abstract

Five pedigrees (including an expanded version of a previously reported pedigree) exhibited typical autosomal dominant retinitis pigmentosa were analysed for linkage of RP to 29 genetic markers. No significant lod scores resulted. The largest lod score is +1.51 and suggests linkage between RP and Rh blood group at an estimated recombination fraction of 20% in males and 40% in females. Further studies are needed to confirm or refute this suggested linkage.

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References

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