[Immunological effectiveness of a method for simultaneous immunization against influenza using live and inactivated vaccines]

Abstract

A significant increase in immunological effectiveness of simultaneous immunization with a killed and live influenza vaccine as compared with separate use of these preparations has been demonstrated. The simultaneous immunization better protected the upper respiratory tracts of the vaccinated volunteers, inhibiting reproduction of the challenge influenza virus with residual virulence. A live vaccine from the "old" influenza A/6/50 (H1N1) was found to produce a protective effect on the current influenza A/1977 (H1N1) virus with residual virulence.