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. 1978 Nov;67(11):1629-31.
doi: 10.1002/jps.2600671134.

Drug resistance studies with topical antiseptics

H N Prince, W S Nonemaker, R C Norgard, D L Prince

Drug resistance studies with topical antiseptics

H N Prince et al. J Pharm Sci. 1978 Nov.

Abstract

Species of Proteus, Serratia, and Pseudomonas became resistant to chlorhexidine after five to eight transfers in vitro. Cross-resistance to benzalkonium chloride also was detected. Resistance to povidone-iodine was not encountered. Chlorhexidine resistance was stable after drug-free transfers of Serratia and Pseudomonas but was transitory for Proteus.

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