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. 1982 Sep;15(5):555-64.
doi: 10.1111/j.1365-2184.1982.tb01577.x.

Human colorectal tumours in short-term organ culture. A stathmokinetic study

C J Pritchett, P V Senior, J P Sunter, A J Watson, D R Appleton, R G Wilson

Human colorectal tumours in short-term organ culture. A stathmokinetic study

C J Pritchett et al. Cell Tissue Kinet. 1982 Sep.

Abstract

Short-term organ culture, using a technique to preserve epithelial/stromal interaction and metabolism, is a useful technique for carrying out kinetic studies on human colorectal carcinoma and adjacent normal mucosa, providing initial perturbations of proliferative indices are allowed to settle. Tumours require 3.0 micrograms/ml vincristine for complete metaphase arrest compared with mucosa, which needs 0.5 microgram/ml, a 6-fold difference. Using a stathmokinetic technique, the birth rate of tumour cells is 10.21 cells/1000 cells per hr, compared with 7.73 cells/1000 cells per hr for mucosa, a statistically significant difference (P less than 0.01).

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