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. 1982;23(1):43-7.
doi: 10.1007/BF01061376.

Pharmacokinetics of intravenous timolol in patients with acute myocardial infarction and in healthy volunteers

J A Vedin, J K Kristianson, C E Wilhelmsson

Pharmacokinetics of intravenous timolol in patients with acute myocardial infarction and in healthy volunteers

J A Vedin et al. Eur J Clin Pharmacol. 1982.

Abstract

Disappearance pharmacokinetics, pharmacodynamics and general tolerance of i.v. timolol were compared in 12 healthy volunteers and 10 patients with a definite or proven acute myocardial infarction. The drug was administered to the patients immediately on arrival at the hospital after a median delay time of 4 h. Tolerance to the injections was good in both volunteers and patients. The study revealed disappearance pharmacokinetics that were similar in volunteers and patients.

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