Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;104(1-2):181-90.
doi: 10.1007/BF00402066.

"Activated" monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction

W Uracz, A Pituch-Noworolska, M Zembala, T Popiela, A Czupryna

"Activated" monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction

W Uracz et al. J Cancer Res Clin Oncol. 1982.

Abstract

The Fc receptor expression, antibody-dependent cellular cytotoxicity (ADCC), and nitro-blue tetrazolium (NBT) reduction of peripheral blood monocytes from 150 patients with different stages of gastric cancer was assessed and compared with results obtained in 77 normal persons and 104 patients with non-malignant diseases of the gut. Monocytes of cancer patients showed an increased ability to form rosettes with human 0, Rh + erythrocytes coated with D-specific antibody. ADCC and NBT reduction were also elevated but no correlation was found with the stage of disease. However, all these phenomena were related to the tumor load as elevated values were the same 4-6 months after surgery in the unresectable-tumor group, while they decreased in patients with resectable tumors. These observations suggest that monocytes of some cancer patients are functionally altered ("activated") in the course of disease.

PubMed Disclaimer

References

    1. Boyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21:77–99 - PubMed
    1. Cohn ZA (1978) The activity of mononuclear phagocytes: fact, fancy and future. J Immunol 121:813–816 - PubMed
    1. Eccles SA (1978) Macrophages and cancer. In: Castro JE (ed) Immunological aspects of cancer. MPT Press Lancaster (pp 123–154)
    1. Evans R, Alexander P (1972) Role of macrophages in tumor immunity. 1. Co-operation between macrophages and lymphoid cells in syngeneic tumor immunity. Immunology 23:615–621 - PMC - PubMed
    1. Fidler IJ (1978) Recognition and destruction of target cells by tumoricidal macrophages. Isr J Med Sci 14:177–191 - PubMed

LinkOut - more resources