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. 1982;104(1-2):63-73.
doi: 10.1007/BF00402054.

Development and properties of malignant lymphoma induced by magnesium deficiency in rats

R Averdunk, P H Bippus, T Günther, H J Merker

Development and properties of malignant lymphoma induced by magnesium deficiency in rats

R Averdunk et al. J Cancer Res Clin Oncol. 1982.

Abstract

Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymphocytes. The degeneration was normalized after feeding on an Mg-rich diet. After 10 or 11 weeks of Mg deficiency, local cell proliferations of immature lymphocytes with a great number of free ribosomes were found in some thymus glands. The local cell proliferations developed into infiltrating tumors without metastases. In lymphoma cells the Na+ and Ca2+ content, the turnover of cellular Na+ and K+, and the aerobic production of CO2 and lactate were increased.

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