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. 1982 Sep;94(3):565-73.
doi: 10.1083/jcb.94.3.565.

The Z-band: 85,000-dalton amorphin and alpha-actinin and their relation to structure

P K Chowrashi, F A Pepe

The Z-band: 85,000-dalton amorphin and alpha-actinin and their relation to structure

P K Chowrashi et al. J Cell Biol. 1982 Sep.

Abstract

The conclusions arrived at as a result of this work can be summarized as follows: (a) We have found that there is an 85,000-dalton protein, which we have called 85K amorphin, associated with the Z-band of chicken pectoralis muscle myofibrils. We have isolated and purified this protein. It is not a structural component of the Z-filaments since it can be extracted completely without extraction of the Z-filaments. Extraction of 85K amorphin results in loss of specific staining of the Z-band with fluorescence specific anti-85K amorphin. (b) We have found that alpha-actinin is the structural component of the Z-filaments, since extraction of alpha-actinin is accompanied by loss of the Z-filament structure.

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