Evaluation of flunisolide nasal solution in the symptomatic treatment of perennial rhinitis

Abstract

The effectiveness of a topical steroid, flunisolide, was evaluated in patients with perennial rhinitis. Thirty-four patients went through a double-blind cross-over study, comparing flunisolide 200 microgram per day with placebo. The symptoms were assessed over two treatment periods each of 4 weeks, with a 2 weeks' washout period in between. There was a statistically significant difference in favour of flunisolide. About half of the patients complained of mild initial irritation from both active drug and placebo.