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. 1982 Nov;77(3):391-3.
doi: 10.1111/j.1476-5381.1982.tb09310.x.

The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro

A C Peatfield, P J Piper, P S Richardson

The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro

A C Peatfield et al. Br J Pharmacol. 1982 Nov.

Abstract

We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.

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