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. 1982 Dec;42(12):5165-6.

Biliary control of beta-glucuronidase activity in the luminal contents of the rat ileum, cecum, and rectum

  • PMID: 7139618

Biliary control of beta-glucuronidase activity in the luminal contents of the rat ileum, cecum, and rectum

A M Roberton et al. Cancer Res. 1982 Dec.

Abstract

The effect of bile exclusion on intestinal beta-glucuronidase activity was studied in the rat. Bile exclusion dramatically decreased the bacterial beta-glucuronidase activity in the cecum and rectum but did not affect the normal low level in the ileum. Thus, bile flow may be the most important factor in modulating beta-glucuronidase activity in the rat large bowel. Dietary substances which can alter bile flow may thus have effects on intestinal bacterial beta-glucuronidase activity. Effects of diet on colon cancer might therefore be explicable in terms of altered bile flow rather than altered bacterial beta-glucuronidase induction.

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