Comparative Study
doi: 10.1016/s0140-6736(77)91428-3.
Artificial sweeteners and human bladder cancer
- PMID: 71398
- DOI: 10.1016/s0140-6736(77)91428-3
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Comparative Study
Artificial sweeteners and human bladder cancer
Lancet.
.
Abstract
A positive association between the use of artificial sweetners, particularly saccharin, and risk of bladder cancer in males has been observed in a case-control study of 480 men and 152 women in three Provinces in Canada. The risk ratio for ever versus never used is 1-6 for males (P=0-009, one-tailed test), and a significant dose-response relationship was obtained for both duration and frequency of use. The population attributable risk for males is estimated at 7%, though for diabetics, who have a similar risk ratio for artificial sweetner use as non-diabetics, the attributable risk is 33%.
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