Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Sep;51(3):419-25.
doi: 10.1016/0027-5107(78)90130-6.

Caffeine inhibition of prereplication repair of mitomycin C-induced DNA damage in human peripheral lymphocytes

Y Ishii, M A Bender

Caffeine inhibition of prereplication repair of mitomycin C-induced DNA damage in human peripheral lymphocytes

Y Ishii et al. Mutat Res. 1978 Sep.

Abstract

Caffeine increases the number of sister-chromatid exchanges (SCE) induced by mitomycin C (MMC) in human peripheral lymphocytes in culture. This enhancement decreases when the treated cells are held in medium before phytohemagglutinin (PHA) stimulation, or when caffeine is added to cultures some time after PHA stimulation but prior to DNA synthesis. There thus appears to be a caffeine-sensitive prereplication repair system, presumably an excision mechanism, capable of repairing a fraction of the MMC-induced DNA lesions.

PubMed Disclaimer

Publication types

LinkOut - more resources