doi: 10.1007/BF00586353.
The effect of chronic ethanol administration of high affinity 3H-nicotinic binding in rat brain
- PMID: 7144928
- DOI: 10.1007/BF00586353
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The effect of chronic ethanol administration of high affinity 3H-nicotinic binding in rat brain
Naunyn Schmiedebergs Arch Pharmacol.
1982 Oct.
Abstract
The effect of chronic ethanol administration on high affinity 3H-nicotinic binding rat brain was investigated. Chronic ethanol administration for 5 months included a significant decrease in the number of specific nicotinic binding sites in the hippocampus, whereas a significantly increase in the number of nicotinic binding sites both in the hypothalamus and in the thalamus was found. Similar effects were observed both after administration of a lower concentration (8% W/V) ethanol and a higher concentration (16% W/V) indicating that the duration of the administration seems to be of importance for the biochemical changes observed.
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