Transmission of Schistosoma mansoni from man to snail: experimental studies of miracidial survival and infectivity in relation to larval age, water temperature, host size and host age

Abstract

We report the results of experimental work on (a) the influence of temperature on the age-dependent survival and infectivity of the miracidia of Schistosoma mansoni and (b) the relationship between snail age, snail size and susceptibility to infection. The death rate of miracidia declined exponentially with age where life-expectancy was maximal (approximately 16 h) at 15 degrees C. Infectivity also declined rapidly with larval age but, in contrast to larval survival, the rate of infection was at a maximum at 25 degrees C. Snail susceptibility was shown to be more closely correlated with host size rather than host age. Susceptibility declined exponentially with increased host size. Size-dependent susceptibility was shown to generate concave age-prevalence curves for infection within snail populations, where the maximum prevalence is generated in snails of intermediary age. Simple mathematical models are developed to aid estimation of larval survival and infection rates and experimental results are discussed in relation to the overall transmission success of the parasite from man to snail.