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. 1982;23(2):153-60.
doi: 10.1186/BF03546801.

The influence of the halothane test on heart parameters, OCT-activity, acid-base balance and blood electrolytes in halothane-sensitive pigs and in pigs premedicated with a beta-blocker (propranolol)

A Schulman

The influence of the halothane test on heart parameters, OCT-activity, acid-base balance and blood electrolytes in halothane-sensitive pigs and in pigs premedicated with a beta-blocker (propranolol)

A Schulman. Acta Vet Scand. 1982.

Abstract
in English, Norwegian

The heart and liver functions, blood electrolytes and acid-base balance were studies in halothane-sensitive and nonsensitive pigs. An inhibition of the hyperthermia reaction was attempted by an i.v. injection of propranolol. The pulse rate of sensitive pigs was shown to be elevated already at the beginning of halothane narcosis. No other differences between sensitive and nonsensitive pigs were observed from the electrocardiogram. Ectopic beats and arythmia appeared only in 1 halothane-sensitive pig which died soon after the test. The serum OCT-activity showed no abnormalities. Hyperkalemia and acidosis occurred but the Ga++ was not elevated in halothane-sensitive animals. The slight elevation in Na+ was thought to be caused by hemoconcentration. A propranolol injection only delayed but did not inhibit the halothane reaction.

Hjärtverksamheten, OCT serumaktiviteten, syre-basbalansen och blod elektrolyterna bestämdes på halotantestade finska lantrasgrisar. Ett försök att förhindra halotankänslighetsreaktionen med hjälp av en ß-blokerare (propranolol) gjordes även.

Förutom en hos de halotankänsliga djuren redan i början av halotannarkosen konstaterad ökning av pulsfrekvensen sågs inga statistiskt signifikanta skillnader i EKG hos de känsliga och icke känsliga djuren. Hos en halotankänslig gris konstaterades dock arytmi och extra slag. Denna gris dog ca 10 min efter testen.

Mellan de känsliga och de okänsliga grisarna sågs ingen skillnad i OCT-aktiviteten.

En hyperkalemi samt lindrigt förhöjd Na+ konstaterades hos de känsliga djuren. Ca++ var däremot densamma i båda grupperna.. Hos de halotankänsliga djuren utvecklades en acidos. En propranolol injection 10 min före testen fördröjde halotanreaktionen men förhindrade den icke.

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References

    1. Allen W M, Berret S, Harding J, Pattersson D. S. D. Experimentally induced acute stress syndrome in Pietrain pigs. Vet. Rec. 1970;87:64–68. doi: 10.1136/vr.87.3.64. - DOI - PubMed
    1. Berman M C, Harrison G G, Bull A B, Kench J E. Changes underlying halothane-induced malignant hyperpyrexia in Land-race pigs. Nature (Lond.) 1970;23:531. - PubMed
    1. Brenner, K.-V., J. Schneider & H. Gürtle: Einflush der Narkose auf die Parameter der Säure-Basen-Status beim Schwein. (Effects of anaesthesia on parameters of the acid-base status in swine). Mh. Vet.-Med. 1978, 33, 379–384.
    1. Britt B A, Kalow W. Malignant hyperthermia: a statistical review. Canad. Anaesth. Soc. J. 1970;17:293–315. doi: 10.1007/BF03004694. - DOI - PubMed
    1. Britt B A, Shandling B, Endrenyi L, Kent G M. Perfusion of malignant hyperthermia-susceptible and normal isolated pig liver with halothane. Canad. Anaesth. Soc. J. 1978;25:373–379. doi: 10.1007/BF03006566. - DOI - PubMed

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