doi: 10.1042/bj2050639.
A simple test for macromolecular heterogeneity in the analytical ultracentrifuge
- PMID: 7150237
- PMCID: PMC1158533
- DOI: 10.1042/bj2050639
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A simple test for macromolecular heterogeneity in the analytical ultracentrifuge
Biochem J.
.
Abstract
A simple check for the presence of heterogeneity in a macromolecular system is proposed, employing comparison of Rayleigh sedimentation-equilibrium patterns for two solutions of the same fringe concentration but differing absolute concentrations. The method is illustrated by application to a bronchial glycoprotein from a cystic-fibrosis patient.
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