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. 1982 Sep 1;205(3):639-41.
doi: 10.1042/bj2050639.

A simple test for macromolecular heterogeneity in the analytical ultracentrifuge

J M Creeth, S E Harding

A simple test for macromolecular heterogeneity in the analytical ultracentrifuge

J M Creeth et al. Biochem J. .

Abstract

A simple check for the presence of heterogeneity in a macromolecular system is proposed, employing comparison of Rayleigh sedimentation-equilibrium patterns for two solutions of the same fringe concentration but differing absolute concentrations. The method is illustrated by application to a bronchial glycoprotein from a cystic-fibrosis patient.

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