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. 1982 Oct;17(1):87-93.
doi: 10.1016/0304-3835(82)90113-6.

Ornithine decarboxylase enzyme activity in human and hamster pancreatic tumor cell lines

O Black Jr, B K Chang

Ornithine decarboxylase enzyme activity in human and hamster pancreatic tumor cell lines

O Black Jr et al. Cancer Lett. 1982 Oct.

Abstract

We measured ornithine decarboxylase (ODC) enzyme activity, protein and DNA levels in 4 pancreatic cancer cell lines, 2 derived from human tumors (COLO-357 and PANC-1) and 2 derived from hamster tumors (WDPaCa and PDPaCa). We measured the parameters in confluent stage conditions and in log-growth phase. We report that the enzyme levels in all cell lines are elevated with respect to normal pancreatic tissue. Half-life studies of ODC in the PDPaCa cell line indicate a 3-fold increase in half-life.

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