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Comparative Study
. 1982 Aug;73(4):517-21.

Mutagenicity of alpha-acetoxy derivatives of N-methyl-N-benzylnitrosamine and N,N-dibenzylnitrosamine in V79 cells: a comparison between methylating and benzylating mutagens

K Huang Kohda, T Anjo, M Mochizuki, Y Kawazoe, M Okada
  • PMID: 7152191
Comparative Study

Mutagenicity of alpha-acetoxy derivatives of N-methyl-N-benzylnitrosamine and N,N-dibenzylnitrosamine in V79 cells: a comparison between methylating and benzylating mutagens

K Huang Kohda et al. Gan. 1982 Aug.

Abstract

The mutagenicity and cytotoxicity of N-methyl-N-(alpha-acetoxybenzyl) nitrosamine, N-benzyl-N-(acetoxymethyl) nitrosamine, N-benzyl-N-(alpha-acetoxybenzyl)-nitrosamine and related compounds were examined in V79 Chinese hamster cells. These three alpha-acetoxy nitrosamines were all mutagenic, the first one (a compound ultimately yielding a methylating species) being far more strongly mutagenic than the other two (compounds ultimately giving benzylating species). The alkylating or aralkylating activity of these compounds was determined by assessing their reactivity toward 4-(rho-nitrobenzyl) pyridine. The chemical reactivity-mutagenicity correlation among these alpha-acetoxy nitrosamines and related compounds is discussed in relation to the carcinogenicity of their mother compounds.

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