Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;61(4):295-309.
doi: 10.1007/BF00276593.

X-autosome translocations: cytogenetic characteristics and their consequences

M G Mattei, J F Mattei, S Ayme, F Giraud

X-autosome translocations: cytogenetic characteristics and their consequences

M G Mattei et al. Hum Genet. 1982.

Abstract

To define the principal characteristics of X-autosome translocations, the authors present a study of 105 cases, five of which are personal observations. The autosomal pairs 15, 21, and 22 are affected by t(X-Aut) more often than would be expected. The distribution of breakpoints on the X chromosome does not differ significantly from the expected distribution. The analysis of different patterns of inactivation seems to confirm that the inactivation could occur at random, but would be followed by a cellular selection favoring the better genetic balance. An estimate of the incidence of t(X-Aut) is proposed, based upon the conclusions that only one chromosome is susceptible to translocation in meiosis in both males and females and that all affected men will be sterile, as will be 50% of women.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1510-4 - PubMed
    1. Clin Genet. 1981 Aug;20(2):130-4 - PubMed
    1. Am J Med Genet. 1978;2(3):233-40 - PubMed
    1. Ann Intern Med. 1978 Oct;89(4):473-6 - PubMed
    1. J Med Genet. 1979 Aug;16(4):254-62 - PubMed

Publication types