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. 1982 Aug;10(4):455-61.
doi: 10.1007/BF01065175.

Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation

F L Tse, F Ballard, J Skinn

Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation

F L Tse et al. J Pharmacokinet Biopharm. 1982 Aug.

Abstract

A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination half-life.

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