Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982:157:177-84.
doi: 10.1007/978-1-4684-4388-2_15.

Differential response to heat of metastatic and non-metastatic rat mammary tumors

M B Yatvin, J Vorpahl, U Kim

Differential response to heat of metastatic and non-metastatic rat mammary tumors

M B Yatvin et al. Adv Exp Med Biol. 1982.

Abstract

Metastasizing and non-metastasizing transplantable mammary tumors were implanted into female W/Fu rats. A pair of tumors were employed, the SMT-2A and MT-W9B. When these tumors were exposed to water bath heating at 43.5 degrees C for 60 minutes, a significantly longer tumor-free growth delay was obtained in the metastasizing tumor compared to its non-metastasizing counterpart. The protein to phospholipid ratio and the content of arachidonic acid was lower in the metastasizing tumor than in the non-metastasizing one. By way of apparent compensation, the metastasizing tumor contained more linoleic and stearic acid. These observations suggest a relation between metastasizing capacity, thermal sensitivity, and membrane composition.

PubMed Disclaimer

Publication types

Substances