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. 1982 Dec;16(4):329-45.
doi: 10.1016/0301-4622(82)87037-3.

Self-replication with errors. A model for polynucleotide replication

J Swetina, P Schuster

Self-replication with errors. A model for polynucleotide replication

J Swetina et al. Biophys Chem. 1982 Dec.

Abstract

A model for polynucleotide replication is presented and analyzed by means of perturbation theory. Two basic assumptions allow handling of sequences up to a chain length of v approximately 80 explicitly: point mutations are restricted to a two-digit model and individual sequences are subsumed into mutant classes. Perturbation theory is in excellent agreement with the exact results for long enough sequences (v greater than 20).

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