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. 1982 Sep;2(3):255-61.
doi: 10.1007/BF00711153.

Rapid recovery of nicotinic receptor-mediated sodium-22 influx following withdrawal from acute or chronic cholinergic stimulation

R G Siman, W L Klein

Rapid recovery of nicotinic receptor-mediated sodium-22 influx following withdrawal from acute or chronic cholinergic stimulation

R G Siman et al. Cell Mol Neurobiol. 1982 Sep.

Abstract

1. Acetylcholine receptor-mediated uptake of 22Na was studied in PC12 cells and 11-day chick muscle cells maintained in culture and exposed to carbamylcholine. 2. Carbamylcholine caused an initial 22-fold increase in the rate of 22Na uptake but this fell to less than twice background after 4-10 min of continuous exposure. The decline reflects receptor desensitization. 3. The effects of acute (10-min) and chronic (10-day) exposure were compared in order to determine whether there was a down-regulation of acetylcholine receptors on chronic exposure to carbamylcholine. No down-regulation was observed on either PC12 or muscle cells. 4. The lack of down-regulation in these nicotinic systems contrasts with results on muscarinic systems and may reflect different roles for these receptor types.

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