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. 1982 Dec;22(6):315-20.
doi: 10.1111/j.1399-0004.1982.tb01846.x.

Metacarpophalangeal pattern profile analysis in Prader-Willi syndrome

M G Butler, S G Kaler, P L Yu, F J Meaney

Metacarpophalangeal pattern profile analysis in Prader-Willi syndrome

M G Butler et al. Clin Genet. 1982 Dec.

Abstract

Metacarpophalangeal pattern profile (MCPP) was determined on 16 Prader-Willi patients. Chromosome analysis of 14 patients showed an interstitial deletion of the long arm of chromosome 15 in seven subjects and normal chromosome results for the remaining individuals. Two separate and distinguishable hand profiles for each group based on the chromosome findings were identified. Correlation studies confirmed the homogeneity of the chromosome deletion group relative to the Prader-Willi individuals with normal chromosomes. Discriminant analysis of Prader-Willi versus normal individuals produces a function of three MCPP variables plus age which may provide a useful tool for diagnosis.

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Figures

Fig. 1.
Fig. 1.
Mean MCPP for combined group, deletion and non-deletion Prader-Willi individuals. Subgroup profiles resemble mirror images.
Fig. 2.
Fig. 2.
Histogram depicting normal and Prader-Willi classification by discriminant analysis. D = 1.062 + 0.581 (X2) − 0.613(X14) − 0.917(X19) − 0.108(age in years).
Fig. 3.
Fig. 3.
Histogram depicting deletion and non-deletion Prader-Willi classification by discriminant analysis. D = −0.761 − 2.408(X13) + 0.724(X14) + 1.265(X17).
See this image and copyright information in PMC

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