Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec;16(6):1096-101.
doi: 10.1128/jcm.16.6.1096-1101.1982.

Investigation of an outbreak of antibiotic-associated colitis by various typing methods

J Wüst, N M Sullivan, U Hardegger, T D Wilkins

Investigation of an outbreak of antibiotic-associated colitis by various typing methods

J Wüst et al. J Clin Microbiol. 1982 Dec.

Abstract

During an outbreak of diarrheal disease due to Clostridium difficile in a surgical ward, 16 C. difficile isolates were cultured from fecal samples of 15 patients. Agarose gel electrophoresis for the detection of plasmid DNA, crossed immunoelectrophoresis for the detection of extracellular antigens and toxins, polyacrylamide gel electrophoresis for analyses of soluble proteins, assays for cytotoxicity, and a comparison of susceptibility to antimicrobial agents were employed. At least 12 of the 16 isolates were shown to be phenotypically the same strain. These findings suggest that in a hospital setting, diarrhea and pseudomembranous colitis caused by C. difficile can be of nosocomial origin and that they can spread from patient to patient.

PubMed Disclaimer

References

    1. J Infect Dis. 1981 Jan;143(1):42-50 - PubMed
    1. Lancet. 1981 Jul 25;2(8239):208-9 - PubMed
    1. Ann Microbiol (Paris). 1980 Mar-Apr;131A(2):171-9 - PubMed
    1. Antimicrob Agents Chemother. 1980 Apr;17(4):695-8 - PubMed
    1. Infect Immun. 1982 Mar;35(3):1032-40 - PubMed

MeSH terms