Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec;45(12):1130-5.
doi: 10.1136/jnnp.45.12.1130.

Assessment of damage to the central nervous system by determination of S-100 protein in the cerebrospinal fluid

C J Sindic, M P Chalon, C L Cambiaso, E C Laterre, P L Masson

Assessment of damage to the central nervous system by determination of S-100 protein in the cerebrospinal fluid

C J Sindic et al. J Neurol Neurosurg Psychiatry. 1982 Dec.

Abstract

S-100 protein was determined by Particle Counting ImmunoAssay in the CSF of patients with various neurological disorders. With a limit of sensitivity of 2.5 micrograms/l this brain-specific protein was detected only in samples from patients with acute damage of the central nervous system, particularly in compression of the spinal cord by tumour, ischaemic disorders, subarachnoïd bleeding and haematoma, and viral or suspected viral infections. Our results support the assumption that S-100 is a reliable index of central nervous system damage and that changes in its concentration could have a prognostic value.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1965 Jun 9;19(6):739-44 - PubMed
    1. J Immunol Methods. 1977;18(1-2):33-44 - PubMed
    1. Brain Res. 1978 Jan 20;140(1):1-13 - PubMed
    1. Eur J Biochem. 1978 Sep 1;89(2):379-88 - PubMed
    1. Neurosci Lett. 1979 Feb;11(2):171-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources