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. 1977 Sep 8;269(5624):122-6.
doi: 10.1038/269122a0.

In vitro synthesis of infectious DNA of murine leukaemia virus

E Rothenberg, D Smotkin, D Baltimore, R A Weinberg

In vitro synthesis of infectious DNA of murine leukaemia virus

E Rothenberg et al. Nature. .

Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse trancriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

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