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. 1982 Dec 1;207(3):583-7.
doi: 10.1042/bj2070583.

Haem disorder in reconstituted human haemoglobin

J C Docherty, S B Brown

Haem disorder in reconstituted human haemoglobin

J C Docherty et al. Biochem J. .

Abstract

Degradation of the haem of haemoglobin (used as a chemical probe of the haem-protein relationship), suggests that reconstituted human haemoglobin contains significant haem disorder. This results from the insertion of haem into globin with an orientation 180 degrees different from the natural orientation. Haem disorder also slowly occurs in methaemoglobin solutions.

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