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. 1982;62(4):349-52.
doi: 10.1007/BF00304554.

Apolipoprotein A-IV polymorphism in man

H J Menzel, P M Kövary, G Assmann

Apolipoprotein A-IV polymorphism in man

H J Menzel et al. Hum Genet. 1982.

Abstract

In man, apolipoprotein A-IV is characterized by a genetically determined polymorphism controlled by two codominant alleles. Two isoforms of this apolipoprotein, designated A-IV-1 and A-IV-2, can be identified by isoelectric focusing. Among 1000 healthy factory workers participating in an epidemiological study, A-IV-1 (genotype 1-1) was observed in 85%; A-IV-2 (genotype 2-2), in 0.5%; and A-IV-1 in combination with A-IV-2 (genotype 1-2), in 14%. In four nonrelated subjects, an apolipoprotein A-IV variant (A-IV-Münster), characterized by a slightly more basic isoelectric focusing behavior than A-IV-2, was detected in combination either with A-IV-1 or A-IV-2. Mendelian inheritance of this variant could be demonstrated.

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References

    1. J Lipid Res. 1982 Aug;23(6):915-22 - PubMed
    1. Biochemistry. 1977 Jan 25;16(2):271-8 - PubMed
    1. Internist (Berl). 1980 Aug;21(8):446-59 - PubMed
    1. J Clin Invest. 1979 Jul;64(1):233-42 - PubMed
    1. Biochem Biophys Res Commun. 1978 Nov 14;85(1):287-92 - PubMed