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. 1982 Dec 15;28(6):713-9.
doi: 10.1016/0049-3848(82)90096-2.

Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) by washed platelets of normal and streptozotocin diabetic mice

W I Rosenblum, E F Ellis, C Cockrell

Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) by washed platelets of normal and streptozotocin diabetic mice

W I Rosenblum et al. Thromb Res. .

Abstract

Washed mouse platelets produced thromboxane B2 (TXB2) and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) in vitro from tritiated arachidonic acid. When diabetes was induced by injecting streptozotocin i.p 200 mg/kg the TXB2 production fell significantly and 12-HETE production significantly increased compared with that of control animals. Eighteen hours of food deprivation caused significant reductions in TXB2 and 12-HETE production in both the control and diabetic groups.

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