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. 1982 Nov 10;125(3):299-305.
doi: 10.1016/0009-8981(82)90260-1.

Detection of adrenoleukodystrophy by increased C26:0 fatty acid levels in leukocytes

B Molzer, H Bernheimer, R Heller, K Toifl, M Vetterlein

Detection of adrenoleukodystrophy by increased C26:0 fatty acid levels in leukocytes

B Molzer et al. Clin Chim Acta. .

Abstract

Very long chain fatty acids of peripheral blood leukocytes were analyzed by gas chromatography in nine members of a family including two hemizygotes and one obligate heterozygote for adrenoleukodystrophy (ALD), as well as in twelve controls. Comparative investigations were done in cultured fibroblasts. Elevated C26:0 levels were observed in leukocytes and fibroblasts of ALD hemizygotes. The obligate heterozygote displayed a clear-cut increase of C26:0 concentration in leukocytes but not in fibroblasts. Determination of C26:0 in leukocytes may serve as diagnostic tool in the detection of ALD gene carriers.

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