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. 1982 Nov 1;148(1):79-82.
doi: 10.1016/0014-5793(82)81246-5.

Base-pair formation between 18 S ribosomal RNA and globin mRNA during initiation of protein synthesis in vitro

B Erni, T Staehelin
Free article

Base-pair formation between 18 S ribosomal RNA and globin mRNA during initiation of protein synthesis in vitro

B Erni et al. FEBS Lett. .
Free article

Abstract

A stable complex between 18 S rRNA and globin mRNA has been isolated from 40 S initiation complexes in the reconstituted reticulocyte cell free system. This complex is only formed under the conditions which also lead to an initiation complex active in protein synthesis. The mRNA-18 S rRNA interaction has properties compatible with base-pairing. This observation is discussed in the context with other, in part controversial, observations relating to base pairing as a step in initiation of eukaryotic protein synthesis.

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