Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec;23(12):1077-80.
doi: 10.1136/gut.23.12.1077.

Overestimate of 125I-protein uptake from the adult mouse gut

T Skogh

Overestimate of 125I-protein uptake from the adult mouse gut

T Skogh. Gut. 1982 Dec.

Abstract

Gastric instillation of 125I-labelled protein in mice leads to rapid appearance of blood radioactivity which is precipitable with 10% trichloroacetic acid (TCA). The same occurs when Na125I is given by mouth. Parenteral administration of non-radioactive NaI before feeding Na125I or 125I-labelled protein inhibits the appearance of TCA-precipitable radioactivity in the blood. The results presented in this study show that measurement of TCA-precipitable radioactivity in the blood after feeding 125I-labeled protein is not a reliable method for studying the passage of macromolecules across the gastrointestinal barriers unless an excess of iodide is given.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biochem J. 1969 Jun;113(2):299-305 - PubMed
    1. Gastroenterology. 1974 May;66(5):987-92 - PubMed
    1. Eur J Immunol. 1974 Oct;4(10):701-4 - PubMed
    1. Immunology. 1977 Nov;33(5):733-43 - PubMed
    1. Proc R Soc Lond B Biol Sci. 1977 Nov 14;199(1135):279-90 - PubMed

Publication types

LinkOut - more resources