Participation of thiamin in hepatic microsomal ethanol oxidizing system
- PMID: 7174223
Item in Clipboard
Participation of thiamin in hepatic microsomal ethanol oxidizing system
Int J Vitam Nutr Res.
1982.
Abstract
In order to assess the role of thiamin on ethanol metabolism, changes in the activity of hepatic microsomal ethanol oxidizing system (MEOS) were measured in rats fed thiamin deficient diet for 4-6 weeks. In thiamin deficient rats, the activity of hepatic MEOS was significantly decreased as compared with control rats. In vitro addition of thiamin or thiamin pyrophosphate (TPP) caused the restoration of the decreased MEOS activity, and this effect was dependent on the concentration of thiamin in rat liver microsomal fraction. Thus, thiamin partly involves in the oxidation of ethanol, and chronic thiamin deficiency predisposes to impair the ethanol oxidation, and consequently to increase the toxicity due to ethanol.
Similar articles
-
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.Drug Nutr Interact. 1983;2(2):117-30. Drug Nutr Interact. 1983. PMID: 6432511
-
The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.J Pharmacol Exp Ther. 1972 May;181(2):279-87. J Pharmacol Exp Ther. 1972. PMID: 4402282 No abstract available.
-
The protective effect of hymochromone against ethanol-induced thiamin deficiency.Drug Nutr Interact. 1982;1(4):271-4. Drug Nutr Interact. 1982. PMID: 6926833
-
Glutamate export at the choroid plexus in health, thiamin deficiency, and ethanol intoxication: review and hypothesis.Alcohol Clin Exp Res. 2008 Aug;32(8):1339-49. doi: 10.1111/j.1530-0277.2008.00727.x. Epub 2008 Jul 9. Alcohol Clin Exp Res. 2008. PMID: 18616670 Review.
-
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.Alcohol Clin Exp Res. 1999 Jun;23(6):991-1007. Alcohol Clin Exp Res. 1999. PMID: 10397283 Review.