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Comparative Study
. 1982;87(5):491-502.
doi: 10.1007/BF00333470.

Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates

H J Cooke, J Schmidtke, J R Gosden
Comparative Study

Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates

H J Cooke et al. Chromosoma. 1982.

Abstract

The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb long, which constitutes about 20% of the DNA of this chromosome. These sequences are localised on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a 'dispersed' repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA.

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