Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates
- PMID: 7182127
- DOI: 10.1007/BF00333470
Characterisation of a human Y chromosome repeated sequence and related sequences in higher primates
Abstract
The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb long, which constitutes about 20% of the DNA of this chromosome. These sequences are localised on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a 'dispersed' repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA.
Similar articles
-
A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes.Genomics. 1992 Jun;13(2):363-7. doi: 10.1016/0888-7543(92)90254-p. Genomics. 1992. PMID: 1612595
-
Structure and evolution of human Y chromosome DNA.Differentiation. 1983;23 Suppl:S48-55. doi: 10.1007/978-3-642-69150-8_9. Differentiation. 1983. PMID: 6444175
-
Evolution of four human Y chromosomal unique sequences.J Mol Evol. 1987;25(4):300-7. doi: 10.1007/BF02603114. J Mol Evol. 1987. PMID: 2822940
-
A Y-chromosomal DNA fragment is conserved in human and chimpanzee.Mol Biol Evol. 1991 Jul;8(4):416-32. doi: 10.1093/oxfordjournals.molbev.a040663. Mol Biol Evol. 1991. PMID: 1840631
-
Sequences from higher primates orthologous to the human Xp/Yp telomere junction region reveal gross rearrangements and high levels of divergence.Hum Mol Genet. 1997 Dec;6(13):2291-9. doi: 10.1093/hmg/6.13.2291. Hum Mol Genet. 1997. PMID: 9361036
Cited by
-
Prenatal diagnosis of genetic disease by chorionic villi sampling.Indian J Pediatr. 1986 Jul-Aug;53(4):489-97. doi: 10.1007/BF02749532. Indian J Pediatr. 1986. PMID: 3804390 No abstract available.
-
Moderately repeated DNA sequences specific for the short arm of the human Y chromosome are present in XX males and reduced in copy number in an XY female.Nucleic Acids Res. 1986 Feb 11;14(3):1325-40. doi: 10.1093/nar/14.3.1325. Nucleic Acids Res. 1986. PMID: 3951989 Free PMC article.
-
DNA methylation and demethylation events during meiotic prophase in the mouse testis.Mol Cell Biol. 1990 Apr;10(4):1828-34. doi: 10.1128/mcb.10.4.1828-1834.1990. Mol Cell Biol. 1990. PMID: 2320009 Free PMC article.
-
Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code".Hum Genet. 1990 Mar;84(4):301-36. doi: 10.1007/BF00196228. Hum Genet. 1990. PMID: 2407640 Review.
-
Analysis of two 47,XXX males reveals X-Y interchange and maternal or paternal nondisjunction.Hum Genet. 1989 Feb;81(3):247-51. doi: 10.1007/BF00278998. Hum Genet. 1989. PMID: 2921034
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources